Alcoholic liver disease is classified into two subgroups: alcoholic hepatitis (AH) and alcoholic steatohepatitis (ASH). These differ in most characteristics, including clinicopathologic features and treatment. However, animal models of AH and ASH are not well established. Noninvasive monitoring is essential for evaluating chronic diseases such as AH and ASH. Magnetic resonance imaging and spectroscopy (MRI/S) have recently gained considerable attention as noninvasive monitoring tools for chronic liver disease. The aim of this study, therefore, was to develop a comprehensive animal model of AH and ASH that can be monitored noninvasively using MRI/S.
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