This study was designed to investigate the signal intensities (SI) of abdominal organs on pre- and post-enhanced HASTE images using ferumoxytol at a dose of 4mg /kg, and to compare the differences of enhancement effect among the organs. We found that the SI of liver, spleen, and pancreas were significantly decreased on HASTE after ferumoxytol administration. The greatest effects on SI were observed in liver and spleen. Little change in SI of muscle and fat was noted. The findings suggest that normal liver and spleen undergo profound decrease in signal intensity following ferumoxytol injection, likely reflecting their high blood volume. This observation suggests a potential role for ferumoxytol in detection and characterization of focal lesions of the liver and spleen.