Time-resolved volumetric MRI (4D-MRI) is gaining more interests for better tumor motion characterization than 4D-CT in abdominal radiotherapy, while 3D sequence has limited use for 4D-MRI acquisition due to its slow volume-frame-rate (VFR) and various motion artifacts. We developed a fast 4D-MRI technique based on CAIPIRINHA accelerated 3D spoiled gradient echo sequence and a 1.63 frames-per-second (615ms/frame, ~1/7 of normal respiratory cycle of 4-5s) VFR was achieved. This 4D-MRI was demonstrated for whole abdomen respiratory motion tracking in healthy volunteers, indicating its great potentials for internal-target-volume definition in radiotherapy treatment planning and image guidance of MR-guided-radiotherapy.
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