A prototype in-bore camera-based physiology sensor was developed and applied for respiratory-triggered MR acquisitions on volunteers. The camera-based physiology sensor allows unobtrusive measurement of breathing activity by derivation of respiratory signals from video stream in real-time. The camera-based breathing sensor provided high quality breathing signal reliably under all tested circumstances of a volunteer study. The breathing signal quality was rated to be superior compared to the bellows in terms of SNR and signal characteristics. Potential false triggers where significantly reduced by the camera. The resulting image quality was on average superior when triggering off the camera compared to when triggering off the bellows.