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Abstract #2555

Magnetic resonance spectroscopy of localized prostate cancer: assessment of antitumor effects of intra-prostatic hormone deprivation therapy

Jan Weis1, Michael Häggman2, Sam Ladjevardi2, Niklas Axen3, and Carl-Gustaf Gölander3

1Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden, 2Department of Urology, Uppsala University Hospital, Uppsala, Sweden, 3LIDDS AB, Uppsala, Sweden

A novel controlled release formulation based on calcium sulphate as drug carrier loaded with the antiandrogen 2-hydroxiflutamide as the active pharmaceutical agent was injected locally into the prostate in patients with prostate cancer. Single-voxel and 2D MRSI using a surface coil were used to investigate the treatment efficiency. The results demonstrate usefulness of both MRS techniques to detect metabolic atrophy caused by long-term local hormone-deprivation therapy. The presence of metabolic atrophy reflects the antitumor effects of the study drug formulation 6 weeks after the intraprostatic injections.

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