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Abstract #2575

Voxel Level Radiologic–Pathologic Validation of DCE-MRI with ISUP Grade in Prostate Cancer

Qing Zhang1, Xiaoyu Lv1, Chengwei Zhang1, Qinglei Zhang2, Ming Li2, Yao Fu3, Jun Xie4, Jiangfen Wu5, Bing Zhang2, and Hongqian Guo1

1Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, China, 2Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 3Department of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 4United Imaging Healthcare Co., Ltd, Shanghai, China, 5GE Healthcare, Nanjing, China

The biggest challenge in patients with newly diagnosed PCa is shifting from cancer detection or staging alone to identifying them with aggressive disease. The PI-RADS v 2 recognizes the role of DCE-MRI is limited but is essential. This work presented a radiology pathology correlation framework that enabled identification of promising in vivo DCE MRI markers of PCa risk at voxel level. The relationship between ISUP grade and DCE-MRI (Ktrans and Kep) suggests that it may be used as a component of active surveillance to noninvasively detect high-grade PCa and affect staging and treatment.

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