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Abstract #2598

R2*-Relaxometry Can Replace Histology for Detecting Slight Iron Overload in Patients with Early Stage Chronic Liver Disease: A Comparison of R2*, Histology, and Mass-Spectrometry

Markus Karlsson1, Mattias Ekstedt2, Mikael F Forsgren3, Nils Dahlström4, Bengt Norén3, Olof Dahlqvist-Leinhard4, Stergios Kechagias2, and Peter Lundberg1

1Department of Radiation Physics, and Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 2Department of Medical and Health Sciences and Department of Gastroenterology and Hepatology, Linköping University, Linköping, Sweden, 3Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 4Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

R2*-relaxometry can be used to non-invasively detect hepatic iron overload. However, most previous studies included patients with very high iron content. We sought to investigate if relaxometry reliably can detect lower levels of hepatic siderosis. R2* was therefore measured in patients with suspected chronic liver diseases of varying etiologies. We compared the relaxation rates to histological semiquantitative assessment as well as total liver iron content using mass spectrometry. There was good correlation between R2* and liver iron content. We also showed that R2*-relaxometry is better than histology when detecting slight iron overload.

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