The purpose of this study is to develop a spiral-based combined spin- and gradient-echo (spiral-SAGE) pulse sequence for simultaneous dynamic contrast-enhanced (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI). Using this sequence, we obtained gradient-echo TEs of 1.69 and 26 ms, a SE TE of 87.72 ms, with a TR of 1663 ms. Using an iterative SENSE reconstruction followed by deblurring, spiral-induced image artifacts were minimized. Comparison of spiral-SAGE images with conventional EPI-SAGE images illustrates substantial improvements in image distortion and image intensity variations. Spiral-SAGE provides a significant improvement for the assessment of perfusion and permeability in various neuropathologies.