The echoes of a 3D multi gradient echo (MGE) scan are typically combined for detection of USPIO and MPIO. The echo combination requires B0 to be constant throughout the scan to achieve good image fidelity at high resolution. A navigator acquisition embedded in the MGE scan maintains the MR steady state and enables a real-time adaptive B0 correction. It is demonstrated that a respiratory-gated correction scheme outperforms ungated correction in mouse brain for the detection of micron sized iron-oxide particles coupled with anti-vascular cell adhesion molecule antibody (VCAM-MPIO) to identify inflammation in vessels.
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