Double Inversion Recovery (DIR) provides a clinical valuable contrast, especially to study gray matter tissue alterations. However, long acquisition times hinder its use in clinical routine. Assuming that the inherent sparsity of the contrast is well suited for compressed sensing, we tested an incoherently undersampled 3D variable-flip-angle fast spin echo sequence with subsequent compressed sensing reconstruction. The reconstructed fourfold accelerated images exhibit image quality similar to both the clinical standard (twofold GRAPPA-accelerated) and to the fully sampled acquisition. The proposed sequence with ~4 min acquisition time may allow a more frequent use of DIR in clinical routine.