The study describes a novel voxel-wise brain fractional anisotropy (FA) analysis approach based on morphometrics evaluation of 3D surfaces. These surfaces were generated using thresholded segmentation of two dimensional FA maps and used for both quantitative analysis and enhanced visualization of differences between a control group and two rodent Lupus models with different degrees of white matter alterations. The methods described, if appropriately translated, could enable integration of DTI-MRI in the diagnostic pipeline in a clinical setting.
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