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Abstract #2874

SNR analysis of retrospectively gated DENSE at 7T for the measurement of brain tissue pulsatility

Ayodeji L. Adams1, Jacob-Jan Sloots1, Peter R. Luijten1, and Jaco J. M. Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Measurements of brain tissue pulsatility can provide information about viscoelastic tissue properties and assess microvasculature blood volume pulsations as a biomarker. VCG-triggered DENSE is capable of acquiring micrometer-level tissue displacements and volumetric strain. However, it is slow and suffers from triggering issues, especially at 7T. In this work, retrospectively-gated DENSE using a pulse oximeter was implemented at 7T. Assessment of its performance showed maintained SNR within half the scan time of triggered DENSE. The high SNR and reduced scan time simplifies its application in future studies assessing the potential of DENSE-derived brain tissue displacements as a biomarker for neurological diseases.

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