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Abstract #2924

A combined 4D Flow MRI-modelling approach for assessing the subject-specific effects of dobutamine on left ventricular function

Belen Casas1,2, Federica Viola1, Gunnar Cedersund3, Ann F Bolger4, Matts Karlsson2,5, Carl-Johan Carlhäll1,2, and Tino Ebbers1,2

1Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 4Department of Medicine, University of California San Francisco, San Francisco, CA, United States, 5Department of Management and Engineering, Linköping University, Linköping, Sweden

This study applies a previously developed imaging-modelling approach to investigate the subject-specific effects of dobutamine on left ventricular contraction and relaxation patterns in healthy subjects. We created personalized models for nine subjects at rest and under dobutamine stress. The personalized parameter values were in agreement with the effects of inotropy and lusitropy reported in previous studies, and demostrated the anticipated variability in individual responses to dobutamine. With further validation, the given approach has the potential to generate advanced metrics of cardiovascular physiology and pathophysiology that could extend beyond conventional techniques for both diagnosis and optimization of a personalized medical regimen.

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