We aim to explore the potential correlation of aortic flow and cardiac function in patients with Fabry disease (FD). The decreased total flow and increased maximum acceleration illustrated altered aortic hemodynamics. The left ventricular peak ejection rate (LVPER) negatively associated with the aortic total flow might be a mechanism to compensate the decreased aortic total flow in FD group. Besides, the positive correlation between LVPER and the systolic maximum acceleration described the interaction between cardiac function and aortic flow. In conclusion, the quantitative aortic flow-related parameters could help to elucidate altered aortic characteristics and the possible correlation with cardiac function.