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Abstract #2967

Validation of MR multitasking myocardial perfusion reserve measurements against simultaneous 13N-ammonia PET

Anthony G Christodoulou1, Damini Dey1,2, Behzad Sharif1, Richard Tang1, Wafa Tawackoli1,3,4, Rohan Dharmakumar1,2,5, Piotr J Slomka1,5, Daniel S Berman1,5, and Debiao Li1,2

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 5Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Measurements from myocardial perfusion MRI have previously been compared against separate PET measurements. However, MR quantification is complicated by signal nonlinearity (leading to a dual-bolus paradigm) and ECG misfires; furthermore, physiological variation in between separate PET and MR assessments are a confounding factor in validation. This work leverages the recent advent of multimodal PET-MR systems to perform a preliminary validation of quantitative MPR measurements from MR multitasking—a new framework allowing single-bolus, non-ECG perfusion quantification—against simultaneous 13N-ammonia PET-MR measurements in pigs. Excellent agreement was found between modalities (no bias, p=0.66; intraclass correlation coefficient=0.95).

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Abstract