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Abstract #3005

Preliminary Investigation of Extravascular Fluid Transport along Arterial Adventitia of Human Lower Extremity

Hongyi Li1, Wentao Liu2, Yang Fan3, Liang Xu4, Yupeng Cao2,5, Fang Wang1, Dong Han2,5, and Min Chen4

1Cardiology Division, Beijing Hospital, Beijing, China, 2CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, China, 3MR Research China, GE Healthcare, Beijing, China, 4Radiological department, Beijing Hospital, Beijing, China, 5School of Future Technology, University of Chinese Academy of Sciences, Beijing, China

Extravascular fluid transport have been reported both in human and animal studies during recent decades. Our previous work demonstrated a long-distance extravascular fluid transport which is consisted of oriented fibrous connective tissues in venous adventitia, arterial adventitia and dermis of amputated lower extremities. To further explore the pattern of fluid transport along lower extremity arteries, we implemented contrast enhanced MRI in volunteers and tracked the longitudinal contrast agent transportation. The periarterial regions near tibia showed high signal intensity after contrast agent administration suggest an unexplored extravascular fluid transport. This study may provide a novel diagnosis method of PAD.

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