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Abstract #3015

Cardiac MRI assessment of the effects of dietary Eicosapentaenoic acid (EPA) on the adverse cardiac consequences of sepsis in rat

Amidou Sissou Traore1, Thibault Leger2, Guilhem Pagès1, Lucie Cassagnes3,4, Azarnoush Kasra5, Jean-Marie Bonny1, and Luc Demaison2,6

1UR270 QuaPA, INRA, Saint-Genès Champanelle, France, 2UNH, INRA, Clermont-Ferrand, France, 3Department of diagnostic and interventional radiology, Clermont Ferrand University Hospital, Clermont-Ferrand, France, 4IGT, Institut Pascal, UMR 6602, CNRS, Clermont-Ferrand, France, 5Heart Surgery Department, Clermont Ferrand University Hospital, Clermont-Ferrand, France, 6CRNH, Clermont Auvergne University, Clermont-Ferrand, France

Severe sepsis is one of the leading cause of death in the intensive care units (ICU) or in short time after discharge from ICU. Developing a rat model of early sepsis involving caecal ligation and puncture, we undertaken this cardiac MRI study to quantitatively assess myocardial function and the protective effect of dietary EPA. Our results showed that, in the exception of the rate of contraction, cardiac functions are less impacted in the early hyperdynamic phase of sepsis with no/or milder modulation of dietary EPA.

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