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Abstract #3035

Prospects of 31P Contrast Media for 31P-MRS

Louise R. Tear1,2, Mahon L. Maguire2, Gogulan Karunanithy3, Deborah Sneddon4, Nicola J. Farrer1, Andrew Baldwin3, Stephen Faulkner1, and Jurgen E. Schneider2,5

1Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom, 2BHF Experimental MR Unit (BMRU), University of Oxford, Oxford, United Kingdom, 3Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom, 4Radiobiology Research Institute, University of Oxford, Oxford, United Kingdom, 5Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom

31P-MRS can be used to determine the relative ratios of phosphate species in vivo to aid clinical diagnosis, but is limited by poor SNR and long acquisition times associated with the 31P nucleus. This work investigates the potential of 31P T1 contrast agents based on Gd.DO3A derivatives by using 31P-MRS. These compounds demonstrate significant relaxation enhancement of 31P R1 for ATP, PCr and Pi, therefore showing excellent potential as 31P contrast agents. Cell studies indicate the Gd.DO3A derivatives investigated do not come into contact with intracellular phosphate metabolites, which limits these initial complexes to use as extracellular contrast agents.

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