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Abstract #3071

Comparison of Asymmetric and Symmetric K-space Sampling in EPI for 3D Time-Resolved Hyperpolarized 13C MRI with [1-13C]Pyruvate

Benjamin J. Geraghty1,2, Casey Y. Lee1,2, Albert P. Chen3, and Charles H. Cunningham1,2

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada

The minimum echo-time for hyperpolarized 13C echo-planar imaging can be reduced with partial sampling along the blipped direction in k-space. To investigate the extent to which echo-time shortening can improve signal-to-noise ratio, we’ve employed an experimental design that toggles between two different spatial encoding strategies during a time-resolved hyperpolarized [1-13C]pyruvate acquisition. Using clinically approved hardware with a pre-clinical animal model, we compared symmetric with asymmetric echo-planar imaging. Considerable signal-to-noise ratio gains for asymmetric vs symmetric sampling were observed without artifacts. On the basis of this study, our group will employ asymmetric sampling in our forthcoming human trials.

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