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Abstract #3074

HyperSIFT: Temoporal Denoising of Hyperpolarized Data Improves SNR while Perserving Dynamic Information

Kristin L Granlund1,2 and Kayvan R Keshari2,3

1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Weill Cornell Medical College, New York, NY, United States

We apply a temporal denoising algorithm to hyperpolarized MRI. The SIFT method filters out temporal frequencies with low amplitudes, reducing noise while preserving dynamic information. We demonstrate this in a bioreactor setting, introducing hyperpolarized [1-13C] pyruvate to cells and human subjects and observing the conversion of pyruvate to lactate.

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