Abstract #3113

Diffusional changes of perivascular space in focused ultrasound induced Blood-Brain Barrier disruption in rat brain

Heajung Choi¹, Huijin Song², Kyung Eun Jang¹, Hyunsil Cha¹, Eunji Kim¹, Mujin Yang¹, Jiung Yang¹, Hoesu Jung³, Mun Han⁴, Taekwan Lee³, Juyoung Park⁴, and Yongmin Chang^1,5

¹Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea, ²Institute of Biomedical Engineering Research, Daegu, Republic of Korea, ³Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea, ⁴Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea, ⁵Department of Radiology, Kyungpook National University, Daegu, Republic of Korea

Focused ultrasound (FUS) induces microbubble oscillation, which loosens the tight junction of the endothelial cells in the brain and opens Blood-Brain Barrier (BBB). In this study, we opened the BBB of rat brain using the MRI guided FUS to investigate the changes of diffusivity in perivascular space using diffusion-weighted imaging (DWI). Our results showed that ADC of the perivascular space increased after sonication suggesting the increased water diffusion in perivascular space after BBB opening. Therefore, our study suggests that ADC change can be a possible imaging marker for opening of BBB.

This abstract and the presentation materials are available to members only; a login is required.

Join Here