The diffusion MRI represents a signal obtained from the relatively large voxel size consisting of complex tissue microstructure. Modern diffusion MRI strategies typically work with one parametric dimension associated with either b-value or diffusion time. In turn, spatial anisotropy of biological tissue demands to take into account a high angular resolution. In order to simplify the interpretation of the diffusion signal, we introduce isotropic diffusion weightings. Essentially, we sample the diffusion signal by 3D oscillating gradient method. Novel biomarkers such as surface-to-volume ratio and mean neurite diameter are presented.