Abstract #3147

Magnetic susceptibility in subcortical gray matter is associated with age-related neuropathologies: An ex-vivo QSM and pathology investigation in a community cohort of older adults

Arnold Evia¹, Ashish Tamhane², Aikaterini Kotrotsou¹, Robert Dawe^1,2,3, Sue Leurgans^2,4, Julie Schneider^2,4,5, David Bennett^2,4, and Konstantinos Arfanakis^1,2,3

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States, ⁴Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁵Department of Pathology, Rush University Medical Center, Chicago, IL, United States

To understand the associations of quantitative susceptibility mapping with age-related neuropathologies, it is essential to combine QSM with direct assessments of age-related brain pathologies on the same individuals. Using ex-vivo QSM for this purpose may be more advantageous than in-vivo QSM, since ex-vivo QSM overcomes several of the obstacles that complicate MRI-pathology investigations and can provide magnetic susceptibility measurements that are linked to those collected in-vivo. Therefore, our goal was to investigate the associations of magnetic susceptibility with the pathology of multiple age-related diseases by combining ex-vivo QSM with histology.

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