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Abstract #3149

On Resonance Variable Delay Multiple Pulse (onVDMP) CEST MRI Detects Transient Lactate Depletion during Experimental Autoimmune Encephalomyelitis Progression

Aline Thomas1, Jiadi Xu2, Peter Calabresi3, Peter van Zijl2, and Jeff Bulte1

1Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Radiology, Kennedy Krieger Institute, Baltimore, MD, United States, 3Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

On resonance variable delay multiple pulse CEST MRI detected a transient reduction in lactate levels in the cerebrospinal fluid during the disease course of a mouse model of multiple sclerosis, which was validated using magnetic resonance spectroscopy.

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