Abstract #3162

Acute changes in rat brain metabolism after intravenous administration of alcohol, cocaine, and nicotine: A simultaneous PET/MR study with dynamic 1H-MRS and continuous infusion 18FDG.

Bart de Laat^1,2, Akila Weerasekera^1,3, Gwen Schroyen^1,3, Cesar Molinos⁴, Uwe Himmelreich^1,3, Cindy Casteels^1,2, Koen Van Laere^1,2, and Willy Gsell^1,3

¹KU Leuven – University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Leuven, Belgium., Leuven, Belgium, ²KU Leuven – University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Leuven, Belgium., Leuven, Belgium, ³KU Leuven – University of Leuven, Biomedical MRI unit, Department of Imaging and Pathology, Leuven, Belgium, Leuven, Belgium, ⁴Bruker BioSpin, Preclinical Imaging NMI, Valencia, Spain

We have combined PET imaging with continuous ¹⁸F-deoxy-glucose PET and dynamic ¹H-MRS focused on the prefrontal cortex in a rodent model of substance abuse. During imaging, animals received an intravenous injection of saline, alcohol, cocaine, or nicotine. Cocaine administration reduced the regional cerebral metabolic rate of glucose (rCMR_Glu) as measured by PET, but increased prefrontal glucose and creatine levels as measured with dynamic MRS. Furthermore, alcohol administration significantly influenced the prefrontal concentration of ethanol, glucose, creatine, and glutamate. Finally, our data show that alcohol induces a transient decrease in prefrontal glutamate coinciding with the peak in ethanol concentration.

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