Fick’s principle can be used to quantify the cerebral metabolic rate of oxygen (CMRO2) as the product of oxygen extraction and blood flow. An interleaved dual-slice multi-echo GRE and phase contrast sequence, termed OxFlow, has previously been used for simultaneous measurement of SvO2 and blood flow. Here, we developed and evaluated an extended multi-echo OxFlow sequence designed for operation at multiple field strengths. The rate of phase accumulation, rather than the inter-echo phase difference, is used to compute SvO2. Results were obtained in 5 healthy subjects at 1.5T, 3T, and 7T, with agreement of the physiologic parameters between field strengths.