Eighty patients with pathologically confirmed gastric carcinomas underwent DWI-MR imaging before surgery prospectively. Whole-lesion ADC histogram analysis was performed. The differences of ADC histogram parameters among different T and N stages were compared with independent-samples Kruskal-Wallis test. ROC analysis was performed to evaluate the performance of ADC histogram parameters in differentiating particular T or N stages of gastric cancers.There were significant differences of all the ADC histogram parameters at different T (except ADCmin and ADCmax) and N (except ADCmax) stages. Whole-volume ADC histogram parameters held great potential in differentiating different T and N stages of gastric cancers preoperatively.