To our knowledge, no studies have employed IVIM diffusion-weighted MRI to explore the variation trend of bone marrow in female. Whether gender difference exists in marrow structure is not well investigated. Therefore, we explored the diagnostic utility of IVIM diffusion-weighted MRI parameters in this context. We found that D, D* and f value showed a decreased trend with age, and the D, D* value of bone marrow in female was significantly higher than that in male except the f value. IVIM diffusion-weighted MRI was useful in the evaluation of bone marrow.