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Abstract #3233

Pre-treatment intra- and inter- voxel magnetic resonance diffusion heterogeneity correlates with chemoradiotherapy treatment outcome of patients with head and neck squamous cell carcinoma

Marianthi-Vasiliki Papoutsaki1, Harbir Singh Sidhu1, Nikolaos Dikaios2, David Atkinson1, Timothy Beale3, Simon Morley3, Martin Forster4, Dawn Carnell5, Ruheena Mendes5, and Shonit Punwani1

1Centre of Medical Imaging, Division of Medicine, University College of London, London, United Kingdom, 2Centre for Vision, Speech and Signal Processing, University of Surrey, London, United Kingdom, 3Department of Radiology, University College Hospital, London, United Kingdom, 4Research Department of Oncology, University College Hospital, London, United Kingdom, 5Radiotherapy Department, University College Hospital, London, United Kingdom

Heterogeneity assessment and diffusion weighted magnetic resonance imaging (DW-MRI) have been considered powerful diagnostic tools in predicting chemoradiotherapy treatment outcome in patients with cancer. In this study, pre-treatment microstructural heterogeneity derived by intra- and inter-voxel MR diffusion rates was assessed in patients with neck squamous cell carcinoma (HNSCC). A correlation was presented between the pre-treatment MR diffusion heterogeneity and the chemoradiotherapy treatment outcome of patients with HNSCC. Future work, to ascertain the mechanisms of these correlations would open the opportunity to tailor therapies to individuals in clinical practice.

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