Abstract #3237

Investigation of Myocardial Fiber Crossings in the Human Heart Using Realistic HARDI Simulation Based on PLI

Lihui WANG¹, Feng YANG², Gabrielle Michalowicz³, Yves Usson³, Pierre-Simon Jouk³, Rongpin Wang⁴, and Yuemin Zhu⁵

¹Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province, School of Compute Science and Technology, Guizhou University, Guiyang, China, ²School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China, ³Laboratoire TIMC-IMAG, UMR5525 CNRS, Université Grenoble Alpes, Grenoble, France, ⁴Department of Radiology, Guizhou Provincial People’s Hospital, Guiyang, China, ⁵Univ.Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F-69621, Lyon, France

We investigate fiber crossings in the myocardium of the human heart using realistic HARDI simulation based on polarized light imaging (PLI). The whole human heart was first imaged using PLI. Based on the fiber orientations measured by PLI, cardiac fiber structures were then modeled, and finally diffusion-weighted images were simulated at different scales using Monte Carlo method and the corresponding ODFs were calculated. The results show that fiber crossings clearly appeared in the myocardium with the increase of scale and that the accuracy of estimating the number of fiber crossings degraded with variable false positive and/or false negative errors.

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