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Abstract #3253

Alterations in cortical thickness and axonal density due to Experimental Autoimmune Encephalomyelitis in the Lewis Rat

J. Keiko McCreary1, Brietta Gerrard1, L. Sorina Truica1, and Gerlinde A.S. Metz1

1Neuroscience, Canadian Centre for Behavioural Neuroscience, Lethbridge, AB, Canada

The animal model of experimental autoimmune encephalomyelitis (EAE) is characterized by inflammatory lesions and demyelination which leads to axonal damage and subsequent neuronal death within the central nervous system. The effect is debilitating, resulting in loss of motor and sensory functions. Here, we investigated changes in cortical thickness using MRI, and axonal density in the corpus callosum using a neuronal tract tracer, biotinylated dextran amine, in Lewis rats induced with EAE. Our study found that EAE leads to a decrease in cortical thickness, particularly in the primary somatosensory trunk region, and axonal density in the corpus callosum.

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