We evaluated 13 shape features of glioblastoma multiforme (GBM) tumor for overall survival (OS) prognosis in 75 patients using univariate and multivariate Cox regression analysis. Age and Karnofsky performance scale were used as covariates for the multivariate analysis. Three shape features were found to be significant for OS prognosis in GBM patients. Kaplan-Merier survival curves were obtained for the significant features to illustrate their effectiveness. In future works, these shape features can be used along with volumetric and texture features derived from the tumor for OS prediction of GBM patients.