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Abstract #3271

Disrupted Nodal Organization of brain functional Network in Children with Type I Gaucher Disease

Miao Zhang1, Di Hu1, Shengpei Wang2, Huiying Kang1, and Yun Peng1

1Beijing Children's Hospital, Capital Medical University,National Center for Children's Health, China, Beijing, China, 2State Key Laboratory of Management and Control for ComplexSystems, Institute of Automation, Chinese Academy of Sciences, Beijing, China, Beijing, China

In our study, we utilize graph-based network analysis to investigate the topological properties of resting-state brain functional connectivity in children with type I GD. Sixteen children diagnosed as type I GD and sixteen age- and sex- matched healthy controls were recruited. No alterations were found at global level. Three nodes within the executive control network showed decreased nodal degree or efficiency. Our provide new insight to further understand the neurophysiological change of these patients.

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