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Abstract #3277

A meta-analysis of studies using graph theory in traumatic brain injury suggests inconclusive evidence for structural disconnectivity

Phoebe Elizabeth Imms1, Adam Clemente1, Derek K Jones1,2, and Karen Caeyenberghs1

1School of Psychology, Australian Catholic University, Melbourne, Australia, 2School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom

The purpose of this meta-analysis is to investigate which graph metrics reliably represent changes to structural connectivity following Traumatic Brain Injury (TBI). Effect sizes were pooled for sixteen different graph metrics, from ten diffusion MRI articles that compared the structural connectome of TBI patients and healthy controls. Interestingly, no metric showed consistent differences across the studies. This analysis indicates that heterogeneity in samples are hindering progress towards clinically relevant disconnectivity biomarkers following brain trauma.

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