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Abstract #3283

Modulation of cortico-subcortical functional connectivity occurs after symptomatic treatment of fatigue in patients with multiple sclerosis

Paola Valsasina1, Bruno Colombo2, Paolo Preziosa1,2, Vittorio Martinelli2, Andrea Falini3, Giancarlo Comi2, Massimo Filippi1,2, and Maria A. Rocca1,2

1Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, 45 fatigued patients with multiple sclerosis (MS) were randomly assigned to undergo treatment with fampridine, amantadine or placebo and underwent clinical, neuropsychological and 3T resting state (RS) functional MRI at baseline and after four weeks of treatment. We found that treatment with fampridine (and, to a lesser extent, with amantadine) ameliorates fatigue in MS. Concomitant increase of RS functional connectivity (FC) in inferior frontal and parietal cortical regions, and decrease of abnormally high intra-thalamic FC were detected, suggesting an improved regulation of cortico-subcortical functional circuits.

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