Abstract #3299

Validation of a Radiological Definition for Central Vessel Sign using 7T FLAIR and SWI

Zahra Hosseini^1,2, Jacob Matusinec³, David Rudko⁴, Junmin Liu¹, Benjamin YinMing Kwan⁵, Fateme Salehi⁵, Manas Sharma⁵, Marcelo Kremenchutzky⁶, Ravi Menon¹, and Maria Drangova^1,2

¹Robarts Research Institute, Western University, London, ON, Canada, ²Graduate Program in Biomedical Engineering, Western University, London, ON, Canada, ³Medicine, Western University, London, ON, Canada, ⁴Department of Neurology/Neurosurgery, McGill University, Montreal, QC, Canada, ⁵Radiology and Clinical Neurological Sciences, Western University, London, ON, Canada, ⁶Department of Clinical Neurological Sciences, Western University, London, ON, Canada

A number of recent clinical radiology studies support the central vessel sign (CVS) as a sensitive and specific means of differentiating MS white matter lesions (WML) from non-MS WML. However, these studies have employed varying practices for imaging veins and WMLs. This has led to an inconsistent radiological definition of CVS. Recently, the North American Imaging in Multiple Sclerosis publisheda set of guidelines, which provide grounds for derivation of a more robust radiological definition of CVS. Here we employ these guidelines, together with FLAIR and SWI at high field to arrive at a sensitive and specific radiological definition of CVS.

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