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Abstract #3302

Spinal Cord Gray Matter Myeloarchitecture Revealed by 7T Magnetization Transfer Imaging

Alan C Seifert1,2,3, Joo-won Kim1,2,3, and Junqian Xu1,2,3,4

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The human spinal cord gray matter contains multiple nuclei and laminae, which are not usually distinguishable in MRI at conventional field strengths. The higher signal-to-noise ratio achievable at 7T provides the increased spatial resolution necessary to resolve these very small gray matter features. Using a wrap-around brainstem/cervical spinal cord RF coil at 7T and a magnetization transfer-prepared multi-echo gradient echo pulse sequence, we resolved three differentially myelinated dorsal horn gray matter structures: the dorsolateral fasciculus, substantia gelatinosa, and nucleus proprius in a single subject at 150-┬Ám in-plane resolution.

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