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Abstract #3304

Concurrent changes in cerebral temperature, lactate and vasomotion in urethane anesthetized rats. Proton magnetic resonance study at 7T.

Devashish Das1,2, Aneurin James Kennerley1, Ben Babourina Brooks3, Samuel Harris1, Luke Boorman1, Paolo DiCarlo1, Christopher CJ Martin1, and Jason Berwick1

1Psychology, Sheffield University, Sheffield, United Kingdom, 2Biological Sciences, Sheffield University, Sheffield, United Kingdom, 3School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom

Cerebral vasomotion is frequently observed phenomenon that accompanies hypotension (mean arterial blood pressure (MABP) 45-65mmHg) in anesthetised rat models(1,2). Although unclear, this mechanism appears to play, in part, a compensatory role in replenishing oxygen reserves in the anaerobic/hypoxic brain. Although the relationship between temperature and metabolism is always interactive. Brain cell metabolism is a major determinant of brain temperature, minor changes in brain temperature can result in significant changes in neural cell metabolism and therefore in brain function. During hypotension (MABP 45-65mmHg) analysis of acquired 1H-spectra revealed thalamic temperature to be ~1.5-2 °C colder than that of the core body temperature (37±0.5)°C. Further analysis of the 1H-spectra revealed dynamic pool of the lactate in the thalamus during hypotension (MABP 45-65mmHg).

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