Daniele Mammoli1, Jeremy Gordon1, Adam Autry1, Peder EZ Larson1, Hsin-Yu Chen1, Mark Van Criekinge1, Lucas Carvajal1, Ilwoo Park2, James B Slater1, Robert Bok1, Jason Crane1, Markus Ferrone3, John Kurhanewicz1, Susan Chang4, and Daniel B Vigneron1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Chonam National University Medical School and Hospital, Chonam, Korea, Democratic People's Republic of, 3Clinical Pharmacy, University of California San Francisco, San Francisco, CA, United States, 4Neurological Surgery, University of California San Francisco, San Francisco, CA, United States
We show preliminary results of
hyperpolarized [1-13C]pyruvate injected in 9 patients
affected with glioma.
Raw data showed excellent SNR. Variable bolus delivery and magnitude images introduced errors in modeling the conversion of pyruvate into lactate: kinetic models were presented and compared quantitatively
to address these issues.
Finally, reliable and spatially-resolved maps of kPL
rates were obtained, which can be useful in future to assess the clinical
relevance of the method for both diagnosis and response to therapy.