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Abstract #3565

Comparison between 8- and 32-channel phased-array receive coils for in vivo hyperpolarized C-13 brain imaging

Adam Autry1, Jeremy W Gordon1, Lucas Carvajal1, Ilwoo Park2, Daniele Mammoli1, Hsin-Yu Chen1, Susan Chang3, Yan Li1, Duan Xu1, Daniel Vigneron1, and Sarah J Nelson1,4

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology, Chonam National University Medical School and Hospital, Chonam, Republic of Korea, 3Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, United States, 4Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

This study sought to evaluate the performance of the first 32-channel head coil for in vivo hyperpolarized 13C brain imaging by comparison against a conventional 8-channel receiver array. Initial phantom experiments characterized the B1+ homogeneity and SNR profiles associated with each hardware configuration via EPI-based imaging techniques. As part of a clinical trial, in vivo dynamic EPI data were also acquired from patients with brain tumors. Phantom and patient data revealed improved uniformity, coverage, and SNR with the 32-channel array that will promote higher resolution and acceleration. In vivo data also demonstrated unprecedented detection of bicarbonate using both hardware platforms.

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