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Abstract #3600

Cellular MRI reveals altered brain arrest of genetically-engineered reporter-expressing metastatic breast cancer cells

Katie Parkins1, Veronica Dubois1, Suzy Wong1, Amanda Hamilton2, Paula Foster1, and John Ronald1

1Medical Biophysics, Western University, London, ON, Canada, 2Western University, London, ON, Canada

While BLI is very complementary to MRI in evaluating the fate of many different cell populations in vivo, including cancer cells, some considerations for the use of BLI have been reported including an increase in tumor growth variation as well as a change in metastatic pattern following luciferase tagging. The objective of this work was to use cellular and anatomical MRI to characterize the in vivo growth patterns of naive and lentiviral-engineered brain-seeking breast cancer cell lines co-expressing fluorescent and bioluminescent reporters in the mouse brain.

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