Abstract #3612

Dose-dependent effects of citicoline on the visuomotor response and white matter integrity in the visual pathway after chronic intraocular pressure elevation

Yolandi van der Merwe^1,2, William J Kohler³, Michael Krawchuk³, Xiaoling Yang², Leon C Ho⁴, Yu Yu⁵, Ying Chau⁶, Christopher K Leung⁷, and Kevin C Chan^2,8,9

¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States, ³Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Department of Electrical Engineering, University of Hong Kong, Hong Kong, Hong Kong, ⁵Division of Biomedical Engineering, Hong Kong University of Science and Technology, Hong Kong, Hong Kong, ⁶Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong, Hong Kong, ⁷Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁸Department of Radiology, New York University, New York, NY, United States, ⁹Department of Ophthalmology, New York University, New York, NY, United States

Glaucoma is a neurodegenerative disease that can cause irreversible vision loss. Elevated intraocular pressure is a major risk factor for the glaucoma; however, the disease may still progress in some patients after lowering IOP. Citicoline has been suggested as a potential therapeutic to ameliorate damage caused by neurodegenerative diseases, including glaucoma, but its neuroprotective effects remain incompletely studied. In this study, we analyzed the dose-dependent effect of oral citicoline on visual behavior response and white matter integrity in a rodent model of glaucoma. The results show citicoline preserves visual behavior response and visual system integrity in a dose dependent manner.

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