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Abstract #3618

Impaired microstructural integrity of the callosum forceps minor in type 2 diabetes mellitus affect bilateral frontal functional connectivity

Xin Wang1, Zhou Zhang2, Jiaming Lu1, Xin Zhang1, Zhao Qin1, Yan Bi2, and Bing Zhang1

1Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2Department of Endocrine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment. While its mechanism remains to be explored. In this study, using Automating Fiber-Tract Quantification (AFQ) analysis, we found that the fractional anisotropy (FA) in callosum forceps minor decreased in patients with T2DM, which indicated transverse white matter tracts connecting bilateral frontal cortex, was damaged. Meanwhile, functional connectivity between multiple brain regions within bilateral frontal cortex was decreased. The changes in the tract of callosum forceps minor might be the microstructural basis for functional changes of frontal cortex and help us understand the mechanism of T2DM related cognition decline.

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