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Abstract #3689

Quantification of Oxygen Metabolism in Human Brain: Comparison of Direct 17O with Indirect 1H MR Method

Dmitry Kurzhunov1, Jan Sedlacik2, Robert Borowiak1, Divya Sanam Bolar3, Johannes Fischer1, Ali Caglar Özen1,4, and Michael Bock1

1Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, 2Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4German Consortium for Translational Cancer Research Freiburg Site, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, quantification of the cerebral metabolic rate of oxygen consumption (CMRO2) in human brain using direct dynamic 17O-MRI with inhalation of 17O gas was compared to indirect 1H-MRI using QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) method. The CMRO2 results of both methods are in a good agreement with 15O-PET studies (17O-MRI: 0.83–1.09/1.13–1.48 µmol/gtissue/min in WM/GM regions; 1H-MRI: 0.40–1.45/0.74–1.73 µmol/gtissue/min in WM/GM regions). QUIXOTIC offers smaller pixels which also results in a higher variation of CMRO2 values, whereas MRI with the intracellular tracer 17O provides averaged values with less variation due to the lower spatial resolution.

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