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Abstract #3692

M2 Tumor Associated Macrophage Targeted Magnetic Resonance Imaging Using Mannose Conjugated Anti-Biofouling Iron Oxide Nanoparticle Probes

Yuancheng Li1, Liya Wang2, Hui Wu3, Weiping Qian4, Bing Ji1, Lily Yang4, and Hui Mao1

1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Radiology, Long Hua Hospital, Shenzheng, China, 3Emory University School of Medicine, Atlanta, GA, United States, 4Surgery, Emory University School of Medicine, Atlanta, GA, United States

By reducing non-specific macrophage uptake, anti-biofouling polymer coated iron oxide nanoparticles (IONPs) conjugated with mannose as the ligand (Man-IONP) was developed for specifically targeting sub-type tumor associated macrophage M2 with mannose receptor 1 expression. This novel MRI probe demonstrated specific M2 macrophage targeting in vitro with M1 and R264.7 macrophages as controls. Immuno-staining of 4T1 breast tumor tissues with Man-IONPs showed the probe targeting M2 similarly to anti-CD206 antibody. NIR and MR imaging of 4T1 tumor-bearing mice showed significant contrast changes after receiving i.v. injection of NIR dye labeled Man-IONP, while little change was observed for mice receiving non-targeted IONP.

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