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Abstract #3705

In Vivo Imaging with Hyperpolarized Aspirin

Argentina Ornelas1, Niki Zacharias Millward1, Jaehyuk Lee1, Jingzhe Hu1, David Menter2, Eduardo Vilar Sanchez3, Pratip K Bhattacharya1, and Steven Wesley Millward1

1Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, United States, 2GI Med Oncology, UT MD Anderson Cancer Center, Houston, TX, United States, 3Clinical Cancer Prevention, UT MD Anderson Cancer Center, Houston, TX, United States

Epidemiological evidence strongly suggests that chronic low-dose aspirin usage leads to a significantly lower incidence of cancer and metastatic disease. Given its emergent role as a chemopreventive, it is highly desirable to develop a method to monitor aspirin pharmacokinetics and metabolism in real time and in vivo. We have recently synthesized and hyperpolarized single and double 13C-labeled aspirin, monitored chemical acetylation in hyperpolarized phantom experiments, and determined metabolism and biodistribution of hyperpolarized 13C aspirin in mice.

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