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Abstract #3719

Hyperpolarized [13C,15N2]urea T2 relaxation changes in acute kidney injury

Christian Ƙstergaard Mariager1, Per Mose Nielsen1, Haiyun Qi1, Steffen Ringgaard1, and Christoffer Laustsen1

1The MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark

BOLD T2* MRI is a surrogate marker of tissue pO2 alterations associated with renal disease, but is limited by perfusion. Hyperpolarized [13C,15N2]urea is an alternative marker of renal function that correlates with normal renal oxygenation. We investigated the correlation between BOLD T2* and 13C-urea T2 in an acute kidney injury (AKI) model. We found that hyperpolarized urea T2 correlates with renal BOLD T2* in the healthy but not in the AKI kidney, and that whole kidney T2 is modulated significantly by the blood volume in addition to oxygen availability. 13C-urea T2 mapping therefore has potential to assist the BOLD estimation.

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