Abstract #3728

Developmental alteration of mean diffusivity in striatum of transgenic Huntington’s disease monkey

Yuguang Meng¹, Jocelyne Bachevalier^2,3, Anthony W.S. Chan^4,5, and Xiaodong Zhang^1,5

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Psychology, Emory University School of Medicine, Atlanta, GA, United States, ³Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ⁴Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, United States, ⁵Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

Huntington Disease (HD) is a neurodegenerative disorder with a primary etiology of striatal pathology. Abnormal mean diffusivity changes have been seen previously in HD patients. However, it remains not fully understood how the diffusivity property of striatum evolves during the development of the disease. This study examined the progressive changes of striatum of rhesus monkey brains with HD gene mutation using diffusion tensor imaging (DTI), and it was found that there was significant MD difference from the control animals in striatum at very early age.

This abstract and the presentation materials are available to members only; a login is required.

Join Here