Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of the motor neurons. Diffusion kurtosis imaging (DKI) may be a suitable biomarker for neuronal injury in ALS. We imaged 30 people with ALS and 63 controls with a 140-direction DKI protocol and explored group differences diffusion and kurtosis scalar values within the motor cortex. Our preliminary data show that significant microstructural changes are measurable by DKI in people with early ALS. DKI may represent a viable biomarker of early ALS progression.