Memory impairment was common among ESRD patients, but the physiopathologic mechanisms were largely unclear. Hippocampus and prefrontal cortex played an important role in the human memory. Here we analyzed the structurre and functional connectivity of hippocampus and its correlation with memory scores (AVLT-H). We found that the hippocampal volume and FC between the rostral/caudal hippocampi and ventrolateral prefrontal cortex, dorsolateral prefrontal cortex as well as middle temporal gyrus. Correlations were found between hippocampal changes and memory impairment. Our study indicated that the hippocampus should be taken into consideration in the further mechanism study of neurol damage in ESRD patients.